 Organic Chemistry Laboratory Chemistry 212 Schedule for Semester II, Spring 2019 |
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| Home Page | Office Hours | Chem | 212 General | Useful Web Sites |
| Dates | Link to Lab Procedure | Description | YouTube links | Write-up/Due Dates |
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| 01/23-01/26 |
Sign up for lab section. Friday Lab Lecture: Fumarase Reaction/Coupling Constant/Stereochemistry Review of Safety |
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| 01/30-02/02 |
The Stereochemistry of Fumarase Mediated D2O addition to Fumarate PDF See Moodle for Karplus Paper |
Set up Fumarase rxn and Yeast Mediated Reduction
Review of Safety Friday Lab Lecture: How Yeast Mediated Reaction Works |
Prepare your lab book for Fumarase rxn (see link for procedure) by doing the following:
Realize each lab is a little different. This lab will have a lower emphasis on mechanisms. Acronym/pneumonic: IMMPDD ( I make molecules productively during daytime) |
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| 01/30-02/02(con't) |
The Stereoselective Reduction of Ethyl Acetoacetate using Enzymes found in Bakers Yeast pdf |
Set up Yeast Mediated Dehyragese Reduction of Ethyl Aceto-Acetoatate Come back and reincubate during week Friday Lab Lecture: How Yeast Mediated Reaction Works |
Prepare your lab book for Yeast Alcohol Dehydrogenes Reduction(see link for procedure) by doing the following:
Mechanism here does not need to have to include details of enzyme.
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| 02/06 - 02/09(continued) |
The Stereochemistry of Fumarase Mediated D2O addition to Fumarate PDF |
Run NMR of Fumarase Mediated D2O Addition to Fumarase |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Though these components are standard, some weeks in lab you are just recording data, use judgement. |
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| 02/06 - 02/09 |
The Stereoselective Reduction of Ethyl Acetoacetate using Enzymes found in Bakers Yeast pdf |
Yeast Alcohol Dehydrogenase Mediated Reduction of Ethyl Aceto-Acetate. Experimental work and spectral analysis Friday Lab Lecture: More Spectrospopy Theory of Two Labs Outline of Flutamide Synthesis |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Due Worksheet for Fumarase rxn during week at instructors discretion. Though these components are standard, some weeks in lab you are just recording data, use judgement.
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02/13 - 02/16 |
Flutamide Synthesis Friday Lab Lecture: Any residual work on Flutamide Rxn and Spectroscopy of Flutamide Synthesis |
Prepare your lab book for lab by doing the following:
This week you have a total lab notebook set-up. |
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02/20 - 02/23 |
Recrystallize Flutamide Product Run IR of Flutamide Product Friday Lab Lecture: More on NMR, Enantio topic & Diastereotopic Hydrogens and splitting. Outline of Total Synthesis project. |
Prepare your lab book for lab by doing the following:
This week you do not have total lab set-up, just record data. Due Yeast Alcohol Dehydrogenase Mediated Reduction of Ethyl Aceto-Acetate Report, 1 (one) per group in TA's folder at instructor's discretion. |
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002/27 - 03/02 |
Week One (See Lab Manual) Friday Lab Lecture: Mechanisms of Project, Column Chromatography How to Write an Abstract |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Acronym/pneumonic: IMMPDD ( I make molecules productively during daytime) Due Flutamide Synthesis Report due at instructors discretion. Though these components are standard, some weeks in lab you are just recording data, use judgement.
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03/06 - 03/10 |
Week Two (See Lab Procedure)
Friday Lab Lecture: Mechanisms of Project How to Write an Abstract/Intro to a Paper |
You Tube |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
See Lab Manual.
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03/13 to 03/23 |
Start 03/12 Spring Break |
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03/20 - 03/23 |
Week Three (See Lab Procedure) Friday Lab Lecture: How to write a journal style paper Experimental Section Note:Tuesday March 20th Community Day at Bryn Mawr. LAB is is at discretion of instructor. (talk to your instructor about logistics) INTRO rough draft during lab hours. Please use resources that are available, Instructors/TAs. |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
See Lab Manual and Nerz notes. Quiz at discretion of instuctor.
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03/27 - 03/30 |
Week Four (See Lab Procedure) Friday Lab Lecture: Mechanisms of Total Synthesis How to Write Paper II Experimential Section Creativity 101: How to ask a question and design a question. |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
See Lab Manual and Nerz notes. During lab come up with question and simple experiment.
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04/03 to 04/06 |
Week Five (See Lab Procedure) Friday Lab Lecture: How to write journal style References and Discussion Creativity 101 How to come up with your own question to explore during last weeks of project |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Due Rough Draft of Intro and Abstract (one per group) due to instructor at instructors discrection.
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04/10 - 04/13 |
Week Six Friday Lab Lecture: How to write a journal style paper Exploring your own questions in the lab The complex spectra of the project |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Responsible for thoroughly looking up procedure thoroughly and prepping notebook as indicated in Lab Manual See Lab Manual and Nerz notes.
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04/2 to 04/20 |
Week Seven Friday Lab Lecture: The complex spectra of Warfarin analogs |
Prepare your lab book for lab by doing the following (if you are starting new procedure):
Responsible for turning in Discussion/Conclusion to during week at instructors discretion. |
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04/23 to 04/27 |
Week Eight Friday Lab Lecture: Any extra help needed |
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05/01 to 05/05 |
Due Total Synthesis Full Paper Due in class week of May 1 |
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